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The same review found that greater dose of marijuana and earlier age at onset of use were also associated with such alterations.
A 2010 review found resting blood flow to be lower globally and in prefrontal areas of the brain in cannabis users, when compared to non-users.
Cannabis is mostly used recreationally or as a medicinal drug, although it may also be used for religious or spiritual purposes.
In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65).
Evidence for causing these cancers is mixed concerning heavy, long-term use.
In general there are far lower risks of pulmonary complications for regular cannabis smokers when compared with those of tobacco.
Herodotus wrote about early ceremonial practices by the Scythians, thought to have occurred from the 5th to 2nd century BCE.
In modern culture the spiritual use of cannabis has been spread by the disciples of the Rastafari movement who use cannabis as a sacrament and as an aid to meditation.
Light and moderate use of cannabis is not believed to increase risk of lung or upper airway cancer.A 2015 analysis of six studies found little evidence that long-term or regular cannabis smoking was associated with lung cancer risk, though it could not rule out whether an association with heavy smoking exists.Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation.sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use.Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine.